Li Lab

Xiangya Hospital, Central South University · Department of Dermatology

Our laboratory operates at the intersection of clinical dermatology and molecular biology, leveraging the vast clinical resources of Xiangya Hospital to drive translational breakthroughs. Under the direction of Prof. Ji Li, we are dedicated to uncovering the biological hallmarks of skin health and developing next-generation interventions.

Research Directions

Pilosebaceous-Related Diseases

Pilosebaceous-Related Diseases

Studying the pathogenesis of alopecia, hair graying, rosacea, and acne, and developing targeted therapeutics and hair follicle reconstruction technologies.

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Skin Aging

Skin Aging

Investigating the mechanisms of skin aging using longevity cohorts, animal models, and cell models, with targeted anti-aging drug design and development for key molecular targets.

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Featured Publications

  2. Image for Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

    Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

    W. Xiao, Y. Zhu, X. Tang, K. Zhu, W. Zhang, M. Chen, K. Cai, S. Xu, Z. Wu, M. Wang, J. Liu, L. Long, Z. Tan, A. Wu, S. Zhou, Z. Zhao, Y. Tang, Y. Huang, B. Wang, F. Liu, Q. Wang, F. Yang, D. Jian, W. Shi, H. Xie, X. Chen, L. Guo, Z. Deng, J. Sun, and J. Li
    Cell. 2026. doi:10.1016/j.cell.2026.01.036
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  4. Image for Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

    Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

    G. Li, L. Yang, S. Duan, M. Chen, Y. Zhang, F. Liu, Y. Wang, J. Li, S. Xu, Z. Wu, M. Wang, B. Wang, Z. Zhao, W. Shi, M. Lei, H. Xie, Y. Tang, Z. Deng, and J. Li
    Nature communications. 2026. doi:10.1038/s41467-026-70153-4
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  6. Image for Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea

    Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea 16

    M. Chen, L. Yang, P. Zhou, S. Jin, Z. Wu, Z. Tan, W. Xiao, S. Xu, Y. Zhu, M. Wang, D. Jian, F. Liu, Y. Tang, Z. Zhao, Y. Huang, W. Shi, H. Xie, Q. Nie, B. Wang, Z. Deng, and J. Li
    Nature communications. 2024. doi:10.1038/s41467-024-52946-7
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  8. Image for High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly

    High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly 16

    Y. Zhang, T. Li, H. Zhao, X. Xiao, X. Hu, B. Wang, Y. Huang, Z. Yin, Y. Zhong, Y. Li, and J. Li
    Nature communications. 2024. doi:10.1038/s41467-024-50970-1
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  10. Image for Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea

    Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea 41

    Z. Deng, M. Chen, Z. Zhao, W. Xiao, T. Liu, Q. Peng, Z. Wu, S. Xu, W. Shi, D. Jian, B. Wang, F. Liu, Y. Tang, Y. Huang, Y. Zhang, Q. Wang, L. Sun, H. Xie, G. Zhang, and J. Li
    Nature communications. 2023. doi:10.1038/s41467-023-39761-2
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  12. Image for ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity

    ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity 60

    F. Xiao, Q. Yu, Z. Deng, K. Yang, Y. Ye, M. Ge, D. Yan, H. Wang, X. Chen, L. Yang, B. Yang, R. Lin, W. Zhang, X. Yang, L. Dong, Y. He, J. Zhou, W. Cai, J. Li, and Q. Kong
    Science advances. 2022. doi:10.1126/sciadv.abf2017
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  14. 中国玫瑰痤疮诊疗指南（2021版） 8

    中华医学会皮肤性病学分会玫瑰痤疮研究中心 and 中国医师协会皮肤科医师分会玫瑰痤疮专业委员会
    中华皮肤科杂志. 2021. doi:10.35541/cjd.20201078
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Contact

Address

Department of Dermatology

Xiangya Hospital, Central South University

87 Xiangya Road, Kaifu District

Changsha, Hunan, China 410008

Central South University Xiangya Hospital Li Lab Skin Aging and Hair Regeneration Research Center