Li Lab

中南大学湘雅医院 · 皮肤科

本实验室依托中南大学湘雅医院丰富的临床资源，致力于临床皮肤科学与分子生物学的交叉融合研究。在李吉教授的带领下，团队聚焦皮肤健康的生物学标志物发现与下一代干预策略的开发。

研究方向

Pilosebaceous-Related Diseases

毛囊皮脂腺相关疾病

整合临床资源、人源毛囊器官培养模型与动物模型，研究脱发、白发、玫瑰痤疮、痤疮等毛囊皮脂腺单位疾病的发病机制，开发靶向治疗药物，并建立基于干细胞的毛囊重建技术。

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Skin Aging

皮肤衰老

利用长寿人群队列、动物及细胞模型研究皮肤衰老的发生机制，并针对关键靶点进行抗衰老药物设计及研发。

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代表性论文

  2. Image for Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

    Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

    W. Xiao, Y. Zhu, X. Tang, K. Zhu, W. Zhang, M. Chen, K. Cai, S. Xu, Z. Wu, M. Wang, J. Liu, L. Long, Z. Tan, A. Wu, S. Zhou, Z. Zhao, Y. Tang, Y. Huang, B. Wang, F. Liu, Q. Wang, F. Yang, D. Jian, W. Shi, H. Xie, X. Chen, L. Guo, Z. Deng, J. Sun, and J. Li
    Cell. 2026. doi:10.1016/j.cell.2026.01.036
    Read more →
  4. Image for Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

    Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

    G. Li, L. Yang, S. Duan, M. Chen, Y. Zhang, F. Liu, Y. Wang, J. Li, S. Xu, Z. Wu, M. Wang, B. Wang, Z. Zhao, W. Shi, M. Lei, H. Xie, Y. Tang, Z. Deng, and J. Li
    Nature communications. 2026. doi:10.1038/s41467-026-70153-4
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  6. Image for Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea

    Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea 16

    M. Chen, L. Yang, P. Zhou, S. Jin, Z. Wu, Z. Tan, W. Xiao, S. Xu, Y. Zhu, M. Wang, D. Jian, F. Liu, Y. Tang, Z. Zhao, Y. Huang, W. Shi, H. Xie, Q. Nie, B. Wang, Z. Deng, and J. Li
    Nature communications. 2024. doi:10.1038/s41467-024-52946-7
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  8. Image for High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly

    High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly 16

    Y. Zhang, T. Li, H. Zhao, X. Xiao, X. Hu, B. Wang, Y. Huang, Z. Yin, Y. Zhong, Y. Li, and J. Li
    Nature communications. 2024. doi:10.1038/s41467-024-50970-1
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  10. Image for Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea

    Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea 41

    Z. Deng, M. Chen, Z. Zhao, W. Xiao, T. Liu, Q. Peng, Z. Wu, S. Xu, W. Shi, D. Jian, B. Wang, F. Liu, Y. Tang, Y. Huang, Y. Zhang, Q. Wang, L. Sun, H. Xie, G. Zhang, and J. Li
    Nature communications. 2023. doi:10.1038/s41467-023-39761-2
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  12. Image for ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity

    ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity 60

    F. Xiao, Q. Yu, Z. Deng, K. Yang, Y. Ye, M. Ge, D. Yan, H. Wang, X. Chen, L. Yang, B. Yang, R. Lin, W. Zhang, X. Yang, L. Dong, Y. He, J. Zhou, W. Cai, J. Li, and Q. Kong
    Science advances. 2022. doi:10.1126/sciadv.abf2017
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  14. 中国玫瑰痤疮诊疗指南（2021版） 8

    中华医学会皮肤性病学分会玫瑰痤疮研究中心 and 中国医师协会皮肤科医师分会玫瑰痤疮专业委员会
    中华皮肤科杂志. 2021. doi:10.35541/cjd.20201078
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联系我们

地址

皮肤科

中南大学湘雅医院

湖南省长沙市开福区湘雅路87号

邮编：410008

Central South University Xiangya Hospital Li Lab Skin Aging and Hair Regeneration Research Center