Li Lab

Clinical Research

Skin aging cohorts

Longitudinal phenotyping linked to molecular profiling, biomarker discovery, and aging-clock development.

Hair disorders

Clinical material paired with organ culture and regenerative strategies for alopecia and hair graying.

Inflammatory skin disease

Patient-derived samples and disease-facing studies focused on rosacea, acne, and related conditions.

Clinical collaboration

For collaboration related to cohorts, samples, or translational dermatology studies, contact liji_xy@csu.edu.cn.


Related publications

2026

  1. Image for Real-world experience of JAK inhibitors in eyebrow regrowth for alopecia areata: A retrospective single-center study

    Real-world experience of JAK inhibitors in eyebrow regrowth for alopecia areata: A retrospective single-center study

    R. Ji, J. Huang, J. Jian, J. Cao, M. Li, T. Tian, X. Liang, J. Li, F. Liu, and W. Shi
    Journal of the American Academy of Dermatology. 2026. doi:10.1016/j.jaad.2026.01.017
  2. Image for Proteomic profiling reveals distinct inflammatory and neurogenic endotypes in rosacea

    Proteomic profiling reveals distinct inflammatory and neurogenic endotypes in rosacea 2

    J. Huang, Y. Zhang, C. Yi, X. Xiao, D. Jian, W. Shi, F. Liu, Y. Huang, Z. Zhao, Y. Tang, M. Chen, Z. Deng, J. Li, Y. Zhang, and B. Wang
    Journal of the American Academy of Dermatology. 2026. doi:10.1016/j.jaad.2025.08.014
  3. Image for Influence of serum lipids and polyunsaturated fatty acids on rosacea: Insights from prospective cohort studies

    Influence of serum lipids and polyunsaturated fatty acids on rosacea: Insights from prospective cohort studies

    R. Mao, Q. Yu, T. Zhang, X. Meng, and J. Li
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 2026. doi:10.1111/ddg.15978
  4. Image for Real-World Efficacy of Ritlecitinib in Adolescent Patients With Alopecia Areata: A 36 Week Monocentric Real-Life Observational Study

    Real-World Efficacy of Ritlecitinib in Adolescent Patients With Alopecia Areata: A 36 Week Monocentric Real-Life Observational Study

    J. Huang, Z. Zhang, J. Jian, M. Li, R. Ji, T. Tian, X. Liang, Z. Zhao, Y. Tang, J. Li, F. Liu, and W. Shi
    Journal of cutaneous medicine and surgery. 2026. doi:10.1177/12034754261429965
  5. Sustaining treatment response in alopecia areata through tofacitinib dose tapering: A single-center retrospective study

    J. Huang, J. Jian, M. Li, R. Ji, T. Tian, X. Liang, Z. Zhao, Y. Tang, J. Li, F. Liu, and W. Shi
    Journal of the American Academy of Dermatology. 2026. doi:10.1016/j.jaad.2025.12.020
  6. Dynamics of Lipid Profile in Patients With Alopecia Areata Treated With Ritlecitinib: A Descriptive, Retrospective, Real-World Study

    M. Zhang, Y. Deng, J. Huang, M. Li, J. Jian, R. Ji, T. Tian, X. Liang, Z. Zhao, Y. Tang, J. Li, F. Liu, and W. Shi
    Journal of cutaneous medicine and surgery. 2026. doi:10.1177/12034754261431757
  7. Use of ritlecitinib in patients with alopecia areata refractory to tofacitinib or baricitinib: A single-center retrospective cohort study 1

    J. Huang, J. Jian, M. Li, R. Ji, T. Tian, X. Liang, Z. Zhao, Y. Tang, F. Liu, J. Li, and W. Shi
    Journal of the American Academy of Dermatology. 2026. doi:10.1016/j.jaad.2025.09.053
  8. Sequential immunotherapy with tofacitinib and low-dose IL-2 induces sustained remission in alopecia areata: a proof-of-concept monocentric study 1

    J. Huang, J. Jian, M. Li, R. Ji, X. Liang, Z. Zhao, Y. Tang, J. Li, F. Liu, and W. Shi
    QJM : monthly journal of the Association of Physicians. 2026. doi:10.1093/qjmed/hcaf221

2025

  1. Image for Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes

    Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes 2

    M. Wang, W. Xiao, T. Liu, Y. Zhu, M. Chen, Z. Tan, S. Xu, Z. Zhao, F. Liu, H. Xie, X. He, Z. Deng, and J. Li
    Life medicine. 2025. doi:10.1093/lifemedi/lnaf005
  2. Image for Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

    Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures 12

    F. Yu, C. Chen, W. Liu, Z. Zhao, Y. Fan, Z. Li, W. Huang, T. Xie, C. Luo, Z. Yao, Q. Guo, Z. Yang, J. Liu, Y. Zhang, R. E. Kellems, J. Xia, J. Li, and Y. Xia
    Aging cell. 2025. doi:10.1111/acel.14482
  3. Image for Real-world efficacy of ritlecitinib in treating alopecia areata across various anatomical sites: Potential rapid response predictors

    Real-world efficacy of ritlecitinib in treating alopecia areata across various anatomical sites: Potential rapid response predictors 3

    J. Huang, J. Jian, M. Li, R. Ji, T. Tian, X. Liang, Z. Zhao, Y. Tang, F. Liu, J. Li, and W. Shi
    Journal of the American Academy of Dermatology. 2025. doi:10.1016/j.jaad.2025.07.008
  4. Correction: miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1

    H. Xie, Y. Liu, R. Du, B. Wang, M. Chen, Y. Zhang, Z. Deng, and J. Li
    Cell death & disease. 2025. doi:10.1038/s41419-025-08184-w
  5. Pd Icosahedral Nanoparticles Promote Skin Wound Healing by Enhancing SP1-HBEGF Axis-Mediated Keratinocytes Proliferation 2

    F. He, M. Li, H. Zhao, H. Zhao, X. Meng, Y. Zhang, Y. Tang, H. Huang, J. Li, H. Xie, and B. Wang
    International journal of nanomedicine. 2025. doi:10.2147/IJN.S499289
  6. Effectiveness and tolerability of ritlecitinib in children with alopecia areata: A case series 4

    J. Huang, J. Jian, M. Li, R. Ji, J. Li, and W. Shi
    Journal of the American Academy of Dermatology. 2025. doi:10.1016/j.jaad.2025.01.090
  7. Association of aging and the risk of late-onset psoriasis: Evidence from the UK Biobank cohort 1

    Z. Yang, F. Wang, T. Zhang, R. Mao, and J. Li
    Journal of the American Academy of Dermatology. 2025. doi:10.1016/j.jaad.2025.01.070
  8. Evaluating the Impact of Omega-3 Fatty Acids and Genetic Susceptibility on Atopic Dermatitis in Adults 5

    R. Mao, X. Meng, T. Zhang, F. Wang, Y. Zhong, and J. Li
    Molecular nutrition & food research. 2025. doi:10.1002/mnfr.70002

2024

  1. Rosacea Core Domain Set for Clinical Trials and Practice: A Consensus Statement 4

    M. A. Dirr, A. Ahmed, D. I. Schlessinger, M. Haq, V. Shi, E. Koza, M. Ma, R. E. Christensen, S. A. Ibrahim, J. Schmitt, L. Johannsen, Y. Asai, H. E. Baldwin, E. Berardesca, B. Berman, A. C. Vieira, A. L. Chien, D. E. Cohen, J. Q. Del Rosso, J. Dosal, L. A. Drake, S. R. Feldman, A. B. Fleischer, A. Friedman, E. Graber, J. C. Harper, Y. R. Helfrich, G. B. Jemec, S. M. Johnson, R. Katta, P. Lio, L. E. Maier, G. Martin, A. R. Nagler, I. M. Neuhaus, M. Palamar, L. C. Parish, T. Rosen, S. P. Shumack, J. A. Solomon, E. A. Tanghetti, G. F. Webster, A. Weinkle, J. S. Weiss, E. J. Wladis, I. A. Maher, J. F. Sobanko, T. V. Cartee, B. A. Cahn, M. Alam, IMPROVED-COS Rosacea Working Group, B. Y. Kang, S. Iyengar, N. Anvery, E. Alpsoy, A. Bewley, C. Dessinioti, A. Egeberg, B. Engin, H. P. M. Gollnick, D. Ioannides, H. S. Kim, E. Lazaridou, J. Li, H. G. Lim, G. Micali, C. M. M. Oliveira, L. Noguera-Morel, A. Parodi, M. Reinholz, D. H. Suh, Q. Sun, E. J. Zuuren, U. Wollina, Y. Zhou, C. Zip, E. Poon, and R. Pearlman
    JAMA dermatology. 2024. doi:10.1001/jamadermatol.2024.0636
  2. Hematological parameters as diagnostic biomarkers for patients with rosacea 2

    S. Liang, Y. Fang, Z. Zhao, B. Wang, Y. Huang, H. Xie, Y. Zhang, and J. Li
    The Journal of dermatology. 2024. doi:10.1111/1346-8138.17168
  3. Effectiveness and safety of generic tofacitinib in alopecia areata: is the generic a cost-effective option? A retrospective study 2

    J. Jian, M. Li, P. Qian, J. Li, Y. Tang, F. Liu, Z. Zhao, J. Huang, and W. Shi
    Archives of dermatological research. 2024. doi:10.1007/s00403-024-02879-4
  4. Skin-permeable gold nanoparticles with modifications azelamide monoethanolamine ameliorate inflammatory skin diseases 9

    H. Zhao, H. Zhao, Y. Tang, M. Li, Y. Cai, X. Xiao, F. He, H. Huang, Y. Zhang, and J. Li
    Biomarker research. 2024. doi:10.1186/s40364-024-00663-0
  5. Integrated bioinformatics analysis and experimental validation identifies CPE as a potential biomarker and therapeutic target for skin aging 1

    X. Peng, Y. Zhong, R. Mao, F. He, Y. Cheng, M. Chen, L. Zhou, H. Xie, J. Li, and Y. Zhang
    Experimental dermatology. 2024. doi:10.1111/exd.15120
  6. Clinical characteristics of the well-defined upper eyelid vascular network pattern in patients with rosacea 4

    Y. Peng, B. Wang, M. Mao, J. Li, W. Shi, H. Zhao, Z. Huang, Z. Zhao, C. Huang, and D. Jian
    International journal of dermatology. 2024. doi:10.1111/ijd.16946
  7. Correction: A Novel Convolutional Neural Network for the Diagnosis and Classification of Rosacea: Usability Study

    Z. Zhao, C. Wu, S. Zhang, F. He, F. Liu, B. Wang, Y. Huang, W. Shi, D. Jian, H. Xie, C. Yeh, and J. Li
    JMIR medical informatics. 2024. doi:10.2196/57654
  8. Dupliumab therapy for alopecia areata: a case series and review of the literature 15

    J. Huang, J. Jian, T. Li, M. Li, K. Luo, S. Deng, Y. Tang, F. Liu, Z. Zhao, W. Shi, and J. Li
    The Journal of dermatological treatment. 2024. doi:10.1080/09546634.2024.2312245

2023

  1. Efficacy and safety of antibiotic agents in the treatment of rosacea: a systemic network meta-analysis 17

    W. Xiao, M. Chen, B. Wang, Y. Huang, Z. Zhao, Z. Deng, H. Xie, J. Li, and Y. Tang
    Frontiers in pharmacology. 2023. doi:10.3389/fphar.2023.1169916
  2. Drug Survival and Long-term Outcome of Tofacitinib in Patients with Alopecia Areata: A Retrospective Study 12

    J. Huang, S. Deng, J. Li, Y. Tang, F. Liu, Y. Liu, S. Rao, and W. Shi
    Acta dermato-venereologica. 2023. doi:10.2340/actadv.v103.13475
  3. Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China 10

    P. Chen, Z. Yang, Z. Fan, B. Wang, Y. Tang, Y. Xiao, X. Chen, D. Luo, S. Xiao, J. Li, H. Xie, and M. Shen
    Frontiers in nutrition. 2023. doi:10.3389/fnut.2023.1092781
  4. Associations of polysocial risk score with incident rosacea: a prospective cohort study of government employees in China 12

    P. Chen, Z. Yang, Z. Fan, B. Wang, Y. Tang, Y. Xiao, X. Chen, D. Luo, S. Xiao, J. Li, and M. Shen
    Frontiers in public health. 2023. doi:10.3389/fpubh.2023.1096687
  5. Image for Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea

    Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea 41

    Z. Deng, M. Chen, Z. Zhao, W. Xiao, T. Liu, Q. Peng, Z. Wu, S. Xu, W. Shi, D. Jian, B. Wang, F. Liu, Y. Tang, Y. Huang, Y. Zhang, Q. Wang, L. Sun, H. Xie, G. Zhang, and J. Li
    Nature communications. 2023. doi:10.1038/s41467-023-39761-2
  6. Image for Paroxetine is an effective treatment for refractory erythema of rosacea: Primary results from the Prospective Rosacea Refractory Erythema Randomized Clinical Trial

    Paroxetine is an effective treatment for refractory erythema of rosacea: Primary results from the Prospective Rosacea Refractory Erythema Randomized Clinical Trial 35

    B. Wang, Y. Huang, Y. Tang, Z. Zhao, W. Shi, D. Jian, F. Liu, Q. Gao, P. Wang, J. Yang, L. Li, H. Xie, and J. Li
    Journal of the American Academy of Dermatology. 2023. doi:10.1016/j.jaad.2023.01.044
  7. Image for Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration

    Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration 7

    Y. Jiang, Y. Huang, G. Ma, T. Liu, Q. Li, H. Wu, and J. Li
    The Journal of dermatology. 2023. doi:10.1111/1346-8138.16767
  8. EGCG identified as an autophagy inducer for rosacea therapy 9

    L. Zhou, Y. Zhong, Y. Wang, Z. Deng, Y. Huang, Q. Wang, H. Xie, Y. Zhang, and J. Li
    Frontiers in pharmacology. 2023. doi:10.3389/fphar.2023.1092473

2022

  1. Image for Health Related Quality of Life of Rosacea Patients in China Assessed by Dermatology Life Quality Index and Willingness to Pay

    Health Related Quality of Life of Rosacea Patients in China Assessed by Dermatology Life Quality Index and Willingness to Pay 13

    Y. Huang, S. Yan, H. Xie, B. Wang, Z. Zhao, Y. Huang, and J. Li
    Patient preference and adherence. 2022. doi:10.2147/PPA.S345258
  2. Image for A novel multi-layer perceptron model for assessing the diagnostic value of non-invasive imaging instruments for rosacea

    A novel multi-layer perceptron model for assessing the diagnostic value of non-invasive imaging instruments for rosacea 9

    Y. Huang, J. He, S. Zhang, Y. Tang, B. Wang, D. Jian, H. Xie, J. Li, F. Chen, and Z. Zhao
  3. Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report 11

    S. Rao, A. Wang, W. Liu, H. Yin, J. Li, L. S. Tsang, Y. Wu, and W. Shi
    Frontiers in medicine. 2022. doi:10.3389/fmed.2022.839954
  4. Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity 14

    T. Liu, J. Li, Z. Deng, M. Chen, K. Sha, W. Xiao, H. Xie, and Z. Zhao
    The Journal of dermatology. 2022. doi:10.1111/1346-8138.16329

2021

  1. 中国玫瑰痤疮诊疗指南(2021版) 8

    中华医学会皮肤性病学分会玫瑰痤疮研究中心 and 中国医师协会皮肤科医师分会玫瑰痤疮专业委员会
    中华皮肤科杂志. 2021. doi:10.35541/cjd.20201078
  2. A Novel Convolutional Neural Network for the Diagnosis and Classification of Rosacea: Usability Study 54

    Z. Zhao, C. Wu, S. Zhang, F. He, F. Liu, B. Wang, Y. Huang, W. Shi, D. Jian, H. Xie, C. Yeh, and J. Li
    JMIR medical informatics. 2021. doi:10.2196/23415
  3. Image for Excessive cleansing: an underestimating risk factor of rosacea in Chinese population

    Excessive cleansing: an underestimating risk factor of rosacea in Chinese population 20

    G. Li, B. Wang, Z. Zhao, W. Shi, D. Jian, H. Xie, Y. Huang, and J. Li
    Archives of dermatological research. 2021. doi:10.1007/s00403-020-02095-w
  4. Image for Willingness-to-Pay and Benefit-Cost Analysis of Botulinum Toxin for the Treatment of Rosacea in China: Findings from a Web-Based Survey

    Willingness-to-Pay and Benefit-Cost Analysis of Botulinum Toxin for the Treatment of Rosacea in China: Findings from a Web-Based Survey 4

    X. Yang, Y. Ouyang, Y. Deng, Y. Xiao, Y. Tang, D. Jian, J. Li, H. Xie, and Y. Huang
    Patient preference and adherence. 2021. doi:10.2147/PPA.S311322
  5. Image for Clinical Features and Risk Factors for Nasal Rosacea: A Hospital-Based Retrospective Study

    Clinical Features and Risk Factors for Nasal Rosacea: A Hospital-Based Retrospective Study 3

    A. Wu, F. Liu, H. Xie, Z. Zhao, Y. Tang, Y. Huang, D. Jian, W. Shi, B. Wang, and J. Li
    Dermatology and therapy. 2021. doi:10.1007/s13555-021-00605-w
  6. Efficacy and safety of hydroxychloroquine for treatment of patients with rosacea: A multicenter, randomized, double-blind, double-dummy, pilot study 38

    B. Wang, X. Yuan, X. Huang, Y. Tang, Z. Zhao, B. Yang, B. Yang, Y. Zheng, C. Yuan, H. Xie, and J. Li
    Journal of the American Academy of Dermatology. 2021. doi:10.1016/j.jaad.2020.05.050
  7. Relationship Between Tea Drinking Behaviour and Rosacea: A Clinical Case-control Study 1

    B. Wang, B. Yan, Z. Zhao, Y. Tang, Y. Huang, D. Jian, W. Shi, H. Xie, Y. Wang, and J. Li
    Acta dermato-venereologica. 2021. doi:10.2340/00015555-3849
  8. Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea 86

    H. Zhang, Y. Zhang, Y. Li, Y. Wang, S. Yan, S. Xu, Z. Deng, X. Yang, H. Xie, and J. Li
    Frontiers in immunology. 2021. doi:10.3389/fimmu.2021.756550
  9. Reply

    Q. Chen, Y. Tang, and J. Li
    Journal of the American Academy of Dermatology. 2021. doi:10.1016/j.jaad.2021.01.091
  10. Relationship between the exercise and severity of androgenic alopecia

    Y. Jiang, Q. Shi, Y. Huang, J. Li, H. Xie, and F. Liu
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2021. doi:10.11817/j.issn.1672-7347.2021.200801

2020

  1. Epidemiological features of rosacea in Changsha, China: A population-based, cross-sectional study 61

    J. Li, B. Wang, Y. Deng, W. Shi, D. Jian, F. Liu, Y. Huang, Y. Tang, Z. Zhao, X. Huang, J. Li, and H. Xie
    The Journal of dermatology. 2020. doi:10.1111/1346-8138.15301
  2. Skincare Habits and Rosacea in 3,439 Chinese Adolescents: A University-based Cross-sectional Study 17

    Z. Zuo, B. Wang, M. Shen, H. Xie, J. Li, X. Chen, and Y. Zhang
    Acta dermato-venereologica. 2020. doi:10.2340/00015555-3442
  3. Willingness-to-Pay and Benefit-Cost Analysis of IPL for Rosacea Treatment: A Cross-Sectional Study in China 8

    Q. Deng, S. Zhang, Y. Deng, F. Liu, W. Shi, H. Xie, Y. Xiao, Y. Huang, and J. Li
    Patient preference and adherence. 2020. doi:10.2147/PPA.S271859
  4. Image for Prevalence, clinical characteristics and health-related quality of life of rosacea in Chinese adolescents: a population-based study

    Prevalence, clinical characteristics and health-related quality of life of rosacea in Chinese adolescents: a population-based study 13

    Q. Chen, Y. Tang, X. Shi, X. Yang, S. Shan, X. Wang, Y. Xiao, X. Chen, M. Shen, and J. Li
    Journal of the European Academy of Dermatology and Venereology : JEADV. 2020. doi:10.1111/jdv.16576
  5. ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages 55

    T. Liu, Z. Deng, H. Xie, M. Chen, S. Xu, Q. Peng, K. Sha, W. Xiao, Z. Zhao, and J. Li
    Biochemical and biophysical research communications. 2020. doi:10.1016/j.bbrc.2019.10.073
  6. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 6

    B. Wang, S. Yan, Y. Yi, Y. Huang, Z. Deng, Y. Zhang, Q. Zheng, H. Xie, and J. Li
    Frontiers in cell and developmental biology. 2020. doi:10.3389/fcell.2020.00691
  7. Hydroxychloroquine is a novel therapeutic approach for rosacea 40

    J. Li, X. Yuan, Y. Tang, B. Wang, Z. Deng, Y. Huang, F. Liu, Z. Zhao, and Y. Zhang
    International immunopharmacology. 2020. doi:10.1016/j.intimp.2019.106178
  8. Identification and verification of EOMEs regulated network in Alopecia areata 12

    X. Yuan, Y. Tang, Z. Zhao, F. Liu, W. Shi, Y. Zhang, and J. Li
    International immunopharmacology. 2020. doi:10.1016/j.intimp.2020.106544
  9. Identification and verification immune-related regulatory network in acne 7

    Y. Xin, S. Zhang, Z. Deng, D. Zeng, J. Li, and Y. Zhang
    International immunopharmacology. 2020. doi:10.1016/j.intimp.2020.107083
  10. Association between rosacea and cardiometabolic disease: A systematic review and meta-analysis 62

    Q. Chen, X. Shi, Y. Tang, B. Wang, H. Xie, W. Shi, and J. Li
    Journal of the American Academy of Dermatology. 2020. doi:10.1016/j.jaad.2020.04.113
  11. Relationship between rosacea and sleep 40

    Z. Wang, H. Xie, Y. Gong, Y. Ouyang, F. Deng, Y. Tang, and J. Li
    The Journal of dermatology. 2020. doi:10.1111/1346-8138.15339
  12. Relationship between the incidence of rosacea and drinking or smoking in China

    Y. Wang, Z. Zhao, F. Liu, H. Xie, J. Li, and B. Wang
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2020. doi:10.11817/j.issn.1672-7347.2020.180759